Internal Mammary Lymph Nodes Irradiation in High-risk Breast Cancer After Neoadjuvant Chemotherapy: a Phase III Randomized, Controlled Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The aim of this study is to explore the impact of internal mammary nodal irradiation on disease-free survival in high-risk breast cancer patients (ypN+or supra/subclavicular lymph node positive) after neoadjuvant chemotherapy.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:
• Histologically confirmed invasive breast cancer
• Underwent neoadjuvant chemotherapy
• Eastern Cooperative Oncology Group Performance Status Scale 0-2
• ypN+ after neoadjuvant chemotherapy or supraclavicular/subclavicular lymph node metastasis before system therapy
• No distant metastases
• No internal mammary nodes metastases based on images before system therapy
• Willing to follow up
• Written,informed consent
Locations
Other Locations
China
Fujian Medical University Union Hospital
RECRUITING
Fuzhou
Contact Information
Primary
Yong Yang, M.S
dr_yangyong1983@163.com
18813019084
Time Frame
Start Date: 2024-07-15
Estimated Completion Date: 2032-07-15
Participants
Target number of participants: 722
Treatments
Experimental: internal mammary nodal irradiation
chest wall/whole breast and supraclavicular+-axillary nodal plus internal mammary nodal irradiation
Active_comparator: No internal mammary node irradiation
chest wall/whole breast and supraclavicular+-axillary nodal irradiation
Related Therapeutic Areas
Sponsors
Leads: Fujian Medical University Union Hospital